Caffeine alters oxidative homeostasis in the body of BALB/c mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F14%3A43875215" target="_blank" >RIV/60162694:G44__/14:43875215 - isvavai.cz</a>
Result on the web
<a href="http://www.elis.sk/download_file.php?product_id=4056&session_id=gc6otkblo722349n4fkp8heih0" target="_blank" >http://www.elis.sk/download_file.php?product_id=4056&session_id=gc6otkblo722349n4fkp8heih0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/BLL_2014_135" target="_blank" >10.4149/BLL_2014_135</a>
Alternative languages
Result language
angličtina
Original language name
Caffeine alters oxidative homeostasis in the body of BALB/c mice
Original language description
Caffeine is a metabolite from coffea genus and some other plants. It has disparate molecular targets in the body. Beside the major action based on antagonism on adenosine receptor, it is involved in other neurotransmission pathways as well. The completemechanism of caffeine action remains unrevealed including link to oxidative homeostasis. For the reason, the current paper solves how caffeine influences oxidative homeostasis in BALB/c mouse model. Caffeine was given intramuscularly in doses 1 - 64 mg/kg and the animals were sacrificed in time intervals from 4 hours up to 3 days. In the experiment, significant increase of thiobarbituric acid reactive substances (TBARS) levels in the kidney and decrease in the brain indicates up and down regulation of oxidative burden. Ferric reducing antioxidant power (FRAP) level in the kidney appoint at release of low molecular weight antioxidants in the organ. The remaining organs including heart, muscles and liver were intact. In the same way, casp
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bratislava Medical Journal-Bratislavske Lekarske Listy
ISSN
0006-9248
e-ISSN
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Volume of the periodical
115
Issue of the periodical within the volume
11
Country of publishing house
SK - SLOVAKIA
Number of pages
5
Pages from-to
699-703
UT code for WoS article
000346550800006
EID of the result in the Scopus database
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