Francisella tularensis type B Delta dsbA mutant protects against type A strain and induces strong inflammatory cytokine and Th1-like antibody response in vivo
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F15%3A43875429" target="_blank" >RIV/60162694:G44__/15:43875429 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/15:00506543
Result on the web
<a href="http://femspd.oxfordjournals.org/content/73/8/ftv058" target="_blank" >http://femspd.oxfordjournals.org/content/73/8/ftv058</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/femspd/ftv058" target="_blank" >10.1093/femspd/ftv058</a>
Alternative languages
Result language
angličtina
Original language name
Francisella tularensis type B Delta dsbA mutant protects against type A strain and induces strong inflammatory cytokine and Th1-like antibody response in vivo
Original language description
Francisella tularensis subspecies tularensis is a highly virulent intracellular bacterial pathogen, causing the disease tularemia. However, a safe and effective vaccine for routine application against F. tularensis has not yet been developed. We have recently constructed the deletion mutants for the DsbA homolog protein (Delta dsbA/FSC200) and a hypothetical protein IglH (Delta iglH/FSC200) in the type B F. tularensis subsp. holarctica FSC200 strain, which exerted different protection capacity against parental virulent strain. In this study, we further investigated the immunological correlates for these different levels of protection provided by Delta dsbA/FSC200 and Delta iglH/FSC200 mutants. Our results show that Delta dsbA/FSC200 mutant, but not Delta iglH/FSC200 mutant, induces an early innate inflammatory response leading to strong Th1-like antibody response. Furthermore, vaccination with Delta dsbA/FSC200 mutant, but not with Delta iglH/FSC200, elicited protection against the sub
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pathogens and Disease
ISSN
2049-632X
e-ISSN
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Volume of the periodical
73
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
"Article Number: UNSP ftv058"
UT code for WoS article
000362978200003
EID of the result in the Scopus database
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