Differential phosphorylation of akt and signaling in CD4 T cells in pathogenic and apathogenic SIV infection

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F16%3A43875607" target="_blank" >RIV/60162694:G44__/16:43875607 - isvavai.cz</a>
Result on the web
<a href="http://www.prolekare.cz/epidemiologie-clanek/rozdily-ve-fosforylaci-akt-v-cd4-lymfocytech-u-patogenni-a-nepatogenni-infekce-siv-58744" target="_blank" >http://www.prolekare.cz/epidemiologie-clanek/rozdily-ve-fosforylaci-akt-v-cd4-lymfocytech-u-patogenni-a-nepatogenni-infekce-siv-58744</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Differential phosphorylation of akt and signaling in CD4 T cells in pathogenic and apathogenic SIV infection
Original language description
Increased CD4+ T cell apoptosis and activation induced cell death as a result of HIV infection in humans and SIV infection in Thesus macaques is indicative of disease. Some non-human primate species naturally infected by SIV, such as African sooty mangabeys, do not succumb to SIV despite high viral loads. Previously, we showed that mRNA levels of GSK-3beta a kinase involved in T cell signaling, are significantly decreased in SIV+ RM. compared to SIV+ SM. The current study confirms that wxpression of GSK-3beta is decreased at the protein level in SIV+RM. In additon, CD4+ T cells from SIV+ RM, but not other animals show an increase in both total Akt, a kinase directly interacting with GSK-3beta and p-AktThr308 in response to stimulation via CD3/CD28, which is associated with an increase in apoptosis. Furthermore, the differences between the uninfected and pathogenically or non-pathogenically infected animlas are not only species specific, but also T cell subset specific and that these trends correlate with ACID. This in one of few studies indicating the activity of Akt can be specific to only one phosphorylation site and may be linked to the differences an AIDC and resistance to the lentivirus induced disease.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Project
<a href="/en/project/GAP304%2F10%2F1161" target="_blank" >GAP304/10/1161: Role of virus-associated host-derived proteins in virus induced T cell dysfunction</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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