Decreasing seroprevalence of measles antibodies after vaccination – possible gap in measles protection in adults in the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F17%3A43875722" target="_blank" >RIV/60162694:G44__/17:43875722 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G33__/17:N0000012 RIV/00179906:_____/17:10363565

Result on the web

<a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170257" target="_blank" >http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170257</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0170257" target="_blank" >10.1371/journal.pone.0170257</a>

Result language

angličtina

Original language name

Decreasing seroprevalence of measles antibodies after vaccination – possible gap in measles protection in adults in the Czech Republic

Original language description

Aims In recent years, Europe has recorded an increase in the number of measles outbreaks despite the implementation of vaccination into the National Immunization Programs. The Czech Republic introduced vaccination against measles into National Immunization Program in 1969. The aim of this study was to determine seroprevalence of IgG antibodies against measles in adults. Methods Our study was designed as a prospective, multicenter cohort study. Samples of blood were taken from adults aged 18 years and over. Specific IgG antibodies were determined by ELISA method. Results A number of 1911 sera samples were obtained. The total seropositivity reached 83.3%, 14.3% of the results were negative and 2.4% were borderline. When comparing the individual age groups, the highest antibody seropositivity (&gt;96%) was detected in persons aged 50 years and over who were naturally infected in pre-vaccine era. The lowest seropositivity was recorded in the age groups 30-39 years (61.5%), 40-49 years (77.5%) and 18-29 years (81.1%). Conclusions A long term high rate of seropositivity persists after natural measles infection. By contrast, it decreases over time after vaccination. Similarly, the concentrations of antibodies in persons with measles history persist for a longer time at a higher level than in vaccinated persons. Our results indicate possible gap in measles protection in adults born after implementation of vaccination into the National Immunization Programs. There are two probable reasons, decrease of measles antibody seropositivity in time after vaccination in setting of limited natural booster and one-dose vaccination schedule used in the first years after implementation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10700 - Other natural sciences

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS One

ISSN

1932-6203

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

"Article Number: e0170257"

UT code for WoS article

000391972600081

EID of the result in the Scopus database

2-s2.0-85009266971