Serological survey of mumps antibodies in adults in the Czech Republic and the need for changes to the vaccination strategy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F18%3A43889490" target="_blank" >RIV/60162694:G44__/18:43889490 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/18:10382147

Result on the web

<a href="https://www.tandfonline.com/doi/abs/10.1080/21645515.2017.1412021?journalCode=khvi20" target="_blank" >https://www.tandfonline.com/doi/abs/10.1080/21645515.2017.1412021?journalCode=khvi20</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/21645515.2017.1412021" target="_blank" >10.1080/21645515.2017.1412021</a>

Result language

angličtina

Original language name

Serological survey of mumps antibodies in adults in the Czech Republic and the need for changes to the vaccination strategy

Original language description

Mumps outbreaks, especially in adolescents and young adults, have been reported in the Czech Republic. The aim of the presented study was to determine the seroprevalence of specific IgG antibodies against mumps in the adult population of the Czech Republic. The study was designed as a multicenter serological survey of adults aged 18years and over. Specific IgG antibodies against mumps were detected in blood samples using an enzyme-linked immunosorbent assay (ELISA). A total of 1,911 serum samples were examined. The overall seropositivity reached 55.3%. In individual age groups, the highest seropositivity 63% (63.5-65.2%) was recorded in adults aged 40years and over; the lowest seropositivity was found in adults aged 18-29years (27.4%). The difference in seropositivity rate between the 18-29years age group and the 40years and over age groups was statistically significant (p &lt; 0.001). Only the 18-29years age group included both vaccinated and unvaccinated (born in the pre-vaccine era) individuals. In vaccinated individuals, seropositivity was reported in only 19.1% of persons; in unvaccinated individuals, seropositivity reached 48.2%. Our results demonstrate the long-term persistence of antibodies following natural infection and the decrease in seropositivity that occurs after vaccination over time. This immunity waning may account for the higher susceptibility of adolescents and young adults to mumps. Therefore, the current vaccination program in the Czech Republic could be considered as less effective. It will be modified with the shifting of the second dose of vaccine from two years of age to the preschool age.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Human Vaccines and Immunotherapeutics

ISSN

2164-5515

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

887-893

UT code for WoS article

000429600000023

EID of the result in the Scopus database

2-s2.0-85040961492