Purin-6-one and pyrrolo[2,3-d]pyrimidin-4-one derivatives as potentiating agents of doxorubicin cytotoxicity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F18%3A43889573" target="_blank" >RIV/60162694:G44__/18:43889573 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/18:10379320 RIV/00216208:11160/18:10379320 RIV/00179906:_____/18:10379320
Result on the web
<a href="https://www.future-science.com/doi/pdf/10.4155/fmc-2018-0086" target="_blank" >https://www.future-science.com/doi/pdf/10.4155/fmc-2018-0086</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4155/fmc-2018-0086" target="_blank" >10.4155/fmc-2018-0086</a>
Alternative languages
Result language
angličtina
Original language name
Purin-6-one and pyrrolo[2,3-d]pyrimidin-4-one derivatives as potentiating agents of doxorubicin cytotoxicity
Original language description
Aim: DNA damage response plays an eminent role in patients' response to conventional chemotherapy and radiotherapy. Its inhibition is of great interest as it can overcome cancer cell resistance and reduce the effective doses of DNA damaging agents. Results & methodology: We have focused our research on phos-phatidylinositol 3-kinase-related kinases and prepared 35 novel compounds through a scaffold hopping approach. The newly synthesized inhibitors were tested on a panel of nine cancer and one healthy cell lines alone and in combination with appropriate doses of doxorubicin. Conclusion: Five novel compounds 4f, 10b, 15g, 7e and 15f in combination with doxorubicin showed significant antiproliferative effect on seven cancer cell lines while not affecting the cell growth alone.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
<a href="/en/project/TG02010020" target="_blank" >TG02010020: Centre for Transfer of Biomedical Technologies - PoC</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Future Medicinal Chemistry
ISSN
1756-8919
e-ISSN
—
Volume of the periodical
10
Issue of the periodical within the volume
17
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
2029-2038
UT code for WoS article
000443173800003
EID of the result in the Scopus database
2-s2.0-85052708059