Cytokines and radiation-induced pulmonary injuries

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F18%3A43889783" target="_blank" >RIV/60162694:G44__/18:43889783 - isvavai.cz</a>

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251431/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251431/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/jrr/rry067" target="_blank" >10.1093/jrr/rry067</a>

Result language

angličtina

Original language name

Cytokines and radiation-induced pulmonary injuries

Original language description

Radiation therapy is one of the most common treatment strategies for thorax malignancies. One of the considerable limitations of this therapy is its toxicity to normal tissue. The lung is the major dose-limiting organ for radiotherapy. That is because ionizing radiation produces reactive oxygen species that induce lesions, and not only is tumor tissue damaged, but overwhelming inflammatory lung damages can occur in alveolar epithelium and capillary endothelium. These damages may result in the radiation-induced pneumonitis and/or fibrosis. While describing lung response to irradiation generally, the main focus of this review is on cytokines and their roles and functions in the individual stages. We discuss the relationship between radiation and cytokines and their direct or indirect effects in the formation and development of radiation injuries. Despite that this topic has been intensively studied and debated for years, there is still not complete understanding of cytokine roles. Because experimental data on cytokines&apos; involvement are fragmented across a large number of experimental studies, this review brings together current knowledge. Cytokines are investigated not only as molecular factors linking with signaling network in pathological processes but also for their diagnostic potential. Much concentrated effort has been made to find the correct protein of the immune system having positive correlation between serum levels and tissue damages. Elucidating a correlation between extent of radiation-induced pulmonary injuries and one or more key cytokines that initiate and control that damage may reveal and improve the efficiency of radiotherapy in cancer treatment and the well-being of patients

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Radiation Research

ISSN

0449-3060

e-ISSN

—

Volume of the periodical

59

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

45

Pages from-to

709-753

UT code for WoS article

000452745600005

EID of the result in the Scopus database

2-s2.0-85057154959