Study of the latent phase of radiation-induced lung injury

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F20%3A00556003" target="_blank" >RIV/60162694:G44__/20:00556003 - isvavai.cz</a>
Result on the web
<a href="https://mmsl.cz/corproof.php?tartkey=mms-000000-0130" target="_blank" >https://mmsl.cz/corproof.php?tartkey=mms-000000-0130</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.31482/mmsl.2020.015" target="_blank" >10.31482/mmsl.2020.015</a>

Result language
angličtina
Original language name
Study of the latent phase of radiation-induced lung injury
Original language description
Early changes in lung tissue after radiation exposure may serve as biodosimetric markers as well as targets for mitigation of radiation-induced lung injury. The aim of our study was to examine cytokine, cellular and tissue alterations induced by ionizing radiation during the first month after irradiation. Female C57BL/6 mice were total body irradiated (TBI) by 8 Gy. Samples of blood and lung tissue were collected 4, 8 and 24 h, 7, 21 and 30 d after irradiation. Blood count, immunophenotypisation and cytokine profile were measured in blood. In lung, immunophenotypisation, cytokine profile and histopathology were evaluated. In blood, the acute radiation syndrome developed with recovery being observed at 21 – 30 d. In the lung tissue, a biphasic response occurred. At first, a significant decreased of lymphocytes, resident tissues macrophages and air/tissue ratio associated with increased neutrophils were observed at 8 – 24 h. Subsequently, increase in infiltrating CD4+ T-lymphocytes, neutrophils and resident tissues macrophages and decreased airiness were measured 21 and 30 d after TBI. In summary, our study describes the mechanisms that lung tissue enables to cope with non-lethal injury.
Czech name
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Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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