Administration of nitro-oleic acid mitigates radiation-induced hematopoietic injury in mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00564730" target="_blank" >RIV/68081707:_____/22:00564730 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0024320522008062?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0024320522008062?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.lfs.2022.121106" target="_blank" >10.1016/j.lfs.2022.121106</a>

Result language
angličtina
Original language name
Administration of nitro-oleic acid mitigates radiation-induced hematopoietic injury in mice
Original language description
Aims: Limited number of agents that provide protection against hematopoietic acute radiation syndrome led us to the evaluation of nitro-oleic acid (NO(2)OA) as a potential protector/mitigator against radiation-induced hematopoietic injury in C57/BL6 mice. Materials and methods: NO(2)OA was administered before and after sub-lethal total body irradiation (TBI) and hematological parameters were evaluated 3 or 7 days after TBI. Key findings: Our results show that NO(2)OA significantly increase bone marrow cellularity including the granulocyte-macrophage colony-forming cells and erythroid progenitors on the 3rd day after TBI. In addition, NO(2)OA enhanced recovery of white blood cells (lymphocytes, neutrophils, and monocytes) in peripheral blood 7 days after irradiation. These effects may be in part attributed to NO(2)OA-induced granulocyte colony-stimulating factor production after TBI. On the other hand, radiation-induced impairment of peripheral red blood cells, hemoglobin, and platelets were not affected with NO(2)OA treatment up to 7 days post TBI. Significance: In conclusion, our data show that NO(2)OA significantly protects hematopoiesis after irradiation, and thus showed a high potential to act as an agent for medical radiation countermeasure.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Project
<a href="/en/project/GA19-09212S" target="_blank" >GA19-09212S: Electrophilic fatty acids as the important regulators of cellular response to irradiation, genome instability, and carcinogenesis.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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