Early cellular responses of germ-free and specific-pathogen-free mice to Francisella tularensis infection
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F18%3A43889788" target="_blank" >RIV/60162694:G44__/18:43889788 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0882401018306004?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0882401018306004?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.micpath.2018.07.036" target="_blank" >10.1016/j.micpath.2018.07.036</a>
Alternative languages
Result language
angličtina
Original language name
Early cellular responses of germ-free and specific-pathogen-free mice to Francisella tularensis infection
Original language description
Bacteria that are highly virulent, expressing high infectivity, and able to survive nebulization, pose great risk to the human population. One of these is Francisella tularensis, the etiological agent of tularemia. F. tularensis is a subject of intense scientific interest due to the fact that vaccines for its immunoprophylaxis in humans are not yet routinely available. One of the substantial obstacles in developing such vaccines is our insufficient knowledge of processes that initiate and regulate the expression of effective protective immunity against intracellular bacteria. Here, we present data documenting the different pattern of cellular behavior occurring in an environment unaffected by microbiota using the model of germ-free mice mono-associated with F. tularensis subsp. holarctica strain LVS in comparison with a classic specific-pathogen-free murine model during early stages of infection.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Microbial Pathogenesis
ISSN
0882-4010
e-ISSN
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Volume of the periodical
123
Issue of the periodical within the volume
October
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
314-322
UT code for WoS article
000452578500047
EID of the result in the Scopus database
2-s2.0-85050356968