All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00536660" target="_blank" >RIV/60162694:G44__/19:00536660 - isvavai.cz</a>

  • Alternative codes found

    RIV/61989592:15310/19:73597240 RIV/00179906:_____/19:10393733

  • Result on the web

    <a href="https://www.tandfonline.com/doi/full/10.1080/14756366.2019.1593159" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/14756366.2019.1593159</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1080/14756366.2019.1593159" target="_blank" >10.1080/14756366.2019.1593159</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers

  • Original language description

    A combination of biochemical, biophysical and biological techniques was used to study calf thymus DNA interaction with newly synthesized 7-MEOTA-tacrine thiourea 12-17 and urea heterodimers 18-22, and to measure interference with type I and II topoisomerases. Their biological profile was also inspected in vitro on the HL-60 cell line using different flow cytometric techniques (cell cycle distribution, detection of mitochondrial membrane potential dissipation, and analysis of metabolic activity/viability). The compounds exhibited a profound inhibitory effect on topoisomerase activity (e.g. compound 22 inhibited type I topoisomerase at 1 mu M concentration). The treatment of HL-60 cells with the studied compounds showed inhibition of cell growth especially with hybrids containing thiourea (14-17) and urea moieties (21 and 22). Moreover, treatment of human dermal fibroblasts with the studied compounds did not indicate significant cytotoxicity. The observed results suggest beneficial selectivity of the heterodimers as potential drugs to target cancer cells.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30107 - Medicinal chemistry

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Enzyme Inhibition and Medicinal Chemistry

  • ISSN

    1475-6366

  • e-ISSN

    1475-6374

  • Volume of the periodical

    34

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    21

  • Pages from-to

    877-897

  • UT code for WoS article

    000462993400001

  • EID of the result in the Scopus database

    2-s2.0-85063866757