Piezoelectric Immunosensor for the Determination of C-Reactive Protein
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00537181" target="_blank" >RIV/60162694:G44__/19:00537181 - isvavai.cz</a>
Result on the web
<a href="http://www.electrochemsci.org/papers/vol14/140908470.pdf" target="_blank" >http://www.electrochemsci.org/papers/vol14/140908470.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.20964/2019.09.02" target="_blank" >10.20964/2019.09.02</a>
Alternative languages
Result language
angličtina
Original language name
Piezoelectric Immunosensor for the Determination of C-Reactive Protein
Original language description
C-reactive protein (CRP) is a common biomarker of inflammatory processes and it typically serves for the distinguishing of bacterial and viral diseases. It is typically measured in the blood, plasma or serum by immunoassay like agglutination or enzymatic immunoassays. In this paper, a new immunoassay based on a piezoelectric biosensor was introduced. QCM with basic frequency of oscillations 10 MHz and gold electrodes served as a platform and it was modified with antibodies against CRP and silica nanoparticles. Separately, antibody functionalized silica nanoparticles were prepared and they further served for signal amplification. CRP was assayed with limit of detection equal to 0.080 mg/l. The assay was successfully validated to standard ELISA method and no significant interference by IgM, TNF alpha and albumin was observed. The biosensor-based assay appears to be practically applicable and can serve for routine diagnosis purpose.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Electrochemical Science
ISSN
1452-3981
e-ISSN
1452-3981
Volume of the periodical
14
Issue of the periodical within the volume
9
Country of publishing house
RS - THE REPUBLIC OF SERBIA
Number of pages
9
Pages from-to
8470-8478
UT code for WoS article
000483307100010
EID of the result in the Scopus database
2-s2.0-85072854723