Chronic hepatitis C in the Czech Republic: Forecasting the disease burden

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00537456" target="_blank" >RIV/60162694:G44__/19:00537456 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00110345 RIV/00216208:11110/19:10399914 RIV/65269705:_____/19:00070947 RIV/00023001:_____/19:00078047 RIV/75010330:_____/19:00012615

Result on the web

<a href="https://cejph.szu.cz/artkey/cjp-201902-0002_chronic-hepatitis-c-in-the-czech-republic-forecasting-the-disease-burden.php" target="_blank" >https://cejph.szu.cz/artkey/cjp-201902-0002_chronic-hepatitis-c-in-the-czech-republic-forecasting-the-disease-burden.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21101/cejph.a5350" target="_blank" >10.21101/cejph.a5350</a>

Result language

angličtina

Original language name

Chronic hepatitis C in the Czech Republic: Forecasting the disease burden

Original language description

Objective: Chronic HCV infection is associated with cirrhosis of the liver, hepatocellular carcinoma (HCC), and liver transplantation. HCV disease burden and the impact of new potent direct acting antivirals (DAAs) in the Czech Republic are unknown. Methods: Using a modelling framework, HCV disease progression in the Czech Republic was predicted to 2030 under the current standard of care treatment structure. In addition, two strategies to reduce the future burden of HCV infection were modelled: an incremental increase in treatment annually and WHO targets. Results: The number of viremic infected individuals in the Czech Republic is estimated to peak in 2026 (n = 55,130) and to decline by 0.5% by 2030 (n = 54,840). The number of individuals with compensated cirrhosis (n = 1,400), decompensated cirrhosis (n = 80), HCC (n = 70), and liver related deaths (n = 60) is estimated to more than double by 2030. Through aggressive increases in diagnosis and treatment, HCV related mortality may decrease by 70% by 2030. Conclusions: Disease burden associated with chronic HCV infection is projected to peak in the Czech Republic in 30-40 years. Assuming that the current portion of DAAs used remains constant, a significant reduction in HCV disease burden is possible through increased diagnosis and treatment through 2030. This analysis provides evidence in order to facilitate the development of national strategies for HCV care and management in the Czech Republic.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30304 - Public and environmental health

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Central European Journal of Public Health

ISSN

1210-7778

e-ISSN

1803-1048

Volume of the periodical

27

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

16

Pages from-to

93-98

UT code for WoS article

000472898100002

EID of the result in the Scopus database

2-s2.0-85068819516