Antidotes Against Methanol Poisoning: A Review
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00541690" target="_blank" >RIV/60162694:G44__/19:00541690 - isvavai.cz</a>
Result on the web
<a href="http://www.eurekaselect.com/170658/article" target="_blank" >http://www.eurekaselect.com/170658/article</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1389557519666190312150407" target="_blank" >10.2174/1389557519666190312150407</a>
Alternative languages
Result language
angličtina
Original language name
Antidotes Against Methanol Poisoning: A Review
Original language description
Methanol is the simplest alcohol. Compared to ethanol that is fully detoxified by metabolism. Methanol gets activated in toxic products by the enzymes, alcohol dehydrogenase and aldehyde dehydrogenase. Paradoxically, the same enzymes convert ethanol to harmless acetic acid. This review is focused on a discussion and overview of the literature devoted to methanol toxicology and antidotal therapy. Regarding the antidotal therapy, three main approaches are presented in the text: 1) ethanol as a competitive inhibitor in alcohol dehydrogenase; 2) use of drugs like fomepizole inhibiting alcohol dehydrogenase; 3) tetrahydrofolic acid and its analogues reacting with the formate as a final product of methanol metabolism. All the types of antidotal therapies are described and bow they protect from toxic sequelae of methanol is explained.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
<a href="/en/project/TH03030336" target="_blank" >TH03030336: Colorimetric sensor for diagnosis of pesticides poisoning</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mini-Reviews in Medicinal Chemistry
ISSN
1389-5575
e-ISSN
1875-5607
Volume of the periodical
19
Issue of the periodical within the volume
14
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
8
Pages from-to
1126-1133
UT code for WoS article
000482187700002
EID of the result in the Scopus database
2-s2.0-85071771498