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Effect of acute hypernatremia induced by hypertonic saline administration on endothelial glycocalyx in rabbits

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00555156" target="_blank" >RIV/60162694:G44__/19:00555156 - isvavai.cz</a>

  • Alternative codes found

    RIV/44555601:13450/19:43895419 RIV/00216208:11150/19:10385663 RIV/00179906:_____/19:10385663

  • Result on the web

    <a href="https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch180428" target="_blank" >https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch180428</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3233/CH-189907" target="_blank" >10.3233/CH-189907</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effect of acute hypernatremia induced by hypertonic saline administration on endothelial glycocalyx in rabbits

  • Original language description

    BACKGROUND AND OBJECTIVE: The endothelial glycocalyx (EG) is fragile and sensitive to damage such as exposure to hypernatremia. Our aim was to describe the influence of hypernatremia on the EG in sublingual and brain microcirculation in rabbits. METHODS: Hypernatremia was induced by intravenous administration of 10% NaCl solution. The sublingual and brain microcirculation were evaluated by the Side-stream Dark Field imaging before (T1) and 20 minutes after infusion of 10% saline (T2). Damage to the EG was quantified by automated analysis of Perfused Boundary Region (PBR) indicating the amount of penetration of red blood cells into the EG. Syndecan-1 levels were also measured. RESULTS: Hypernatremia was reached in all 20 animals, the PBR values of the sublingual area raised from 1,98 (0,3) to 2,17 (0,18) μm (p = 0,05). The levels of syndecan-1 (1,23 (0,36); 1,31 (0,33) ng/l, p = 0,3) did not mirror PBR changes. CONCLUSIONS: Hypernatremia increased the PBR within the sublingual microcirculation in our animal model, probably due to compression of the EG related to temporary intravascular hypervolemia and changes of the EG charge in RBC instead of direct damaging effect on EG, which has been excluded by rather unchanged levels of syndecan-1.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30205 - Hematology

Result continuities

  • Project

    <a href="/en/project/NV15-31881A" target="_blank" >NV15-31881A: Alterations of glycocalyx in critical illness and during major surgery and approaches for glycocalyx protection</a><br>

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical Hemorheology And Microcirculation

  • ISSN

    1386-0291

  • e-ISSN

    1875-8622

  • Volume of the periodical

    72

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    10

  • Pages from-to

    107-116

  • UT code for WoS article

    000476864200009

  • EID of the result in the Scopus database

    2-s2.0-85069716605