Effect of acute hypernatremia induced by hypertonic saline administration on endothelial glycocalyx in rabbits
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00555156" target="_blank" >RIV/60162694:G44__/19:00555156 - isvavai.cz</a>
Alternative codes found
RIV/44555601:13450/19:43895419 RIV/00216208:11150/19:10385663 RIV/00179906:_____/19:10385663
Result on the web
<a href="https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch180428" target="_blank" >https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch180428</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3233/CH-189907" target="_blank" >10.3233/CH-189907</a>
Alternative languages
Result language
angličtina
Original language name
Effect of acute hypernatremia induced by hypertonic saline administration on endothelial glycocalyx in rabbits
Original language description
BACKGROUND AND OBJECTIVE: The endothelial glycocalyx (EG) is fragile and sensitive to damage such as exposure to hypernatremia. Our aim was to describe the influence of hypernatremia on the EG in sublingual and brain microcirculation in rabbits. METHODS: Hypernatremia was induced by intravenous administration of 10% NaCl solution. The sublingual and brain microcirculation were evaluated by the Side-stream Dark Field imaging before (T1) and 20 minutes after infusion of 10% saline (T2). Damage to the EG was quantified by automated analysis of Perfused Boundary Region (PBR) indicating the amount of penetration of red blood cells into the EG. Syndecan-1 levels were also measured. RESULTS: Hypernatremia was reached in all 20 animals, the PBR values of the sublingual area raised from 1,98 (0,3) to 2,17 (0,18) μm (p = 0,05). The levels of syndecan-1 (1,23 (0,36); 1,31 (0,33) ng/l, p = 0,3) did not mirror PBR changes. CONCLUSIONS: Hypernatremia increased the PBR within the sublingual microcirculation in our animal model, probably due to compression of the EG related to temporary intravascular hypervolemia and changes of the EG charge in RBC instead of direct damaging effect on EG, which has been excluded by rather unchanged levels of syndecan-1.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/NV15-31881A" target="_blank" >NV15-31881A: Alterations of glycocalyx in critical illness and during major surgery and approaches for glycocalyx protection</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Hemorheology And Microcirculation
ISSN
1386-0291
e-ISSN
1875-8622
Volume of the periodical
72
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
107-116
UT code for WoS article
000476864200009
EID of the result in the Scopus database
2-s2.0-85069716605