Diagnoses of pathological states based on acetylcholinesterase and butyrylcholinesterase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F20%3A00555876" target="_blank" >RIV/60162694:G44__/20:00555876 - isvavai.cz</a>
Result on the web
<a href="http://www.eurekaselect.com/169484/article" target="_blank" >http://www.eurekaselect.com/169484/article</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/0929867326666190130161202" target="_blank" >10.2174/0929867326666190130161202</a>
Alternative languages
Result language
angličtina
Original language name
Diagnoses of pathological states based on acetylcholinesterase and butyrylcholinesterase
Original language description
Two cholinesterases exist: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). While AChE plays a crucial role in neurotransmissions, BChE has no specific function apart from the detoxification of some drugs and secondary metabolites from plants. Thus, both AChE and BChE can serve as biochemical markers of various pathologies. Poisoning by nerve agents like sarin, soman, tabun, VX, novichok and overdosing by drugs used in some neurodegenerative disorders like Alzheimer's disease and myasthenia gravis, as well as poisoning by organophosphorus pesticides are relevant to this issue. But it appears that changes in these enzymes take place in other processes including oxidative stress, inflammation, some types of cancer and genetically conditioned diseases. In this review, the cholinesterases are introduced, the mechanism of inhibitors action is explained and the relations between the cholinesterases and pathologies are explained.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
<a href="/en/project/TH03030336" target="_blank" >TH03030336: Colorimetric sensor for diagnosis of pesticides poisoning</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Medicinal Chemistry
ISSN
0929-8673
e-ISSN
1875-533X
Volume of the periodical
27
Issue of the periodical within the volume
18
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
18
Pages from-to
2994-3011
UT code for WoS article
000539113400005
EID of the result in the Scopus database
2-s2.0-85086243749