Role of Caffeine in the Age-related Neurodegenerative Diseases: A Review
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F23%3A00558405" target="_blank" >RIV/60162694:G44__/23:00558405 - isvavai.cz</a>
Result on the web
<a href="https://www.eurekaselect.com/article/122525" target="_blank" >https://www.eurekaselect.com/article/122525</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1389557522666220413103529" target="_blank" >10.2174/1389557522666220413103529</a>
Alternative languages
Result language
angličtina
Original language name
Role of Caffeine in the Age-related Neurodegenerative Diseases: A Review
Original language description
Caffeine, a simple purine alkaloid with the proper chemical name 1,3,7-trimethylpurine-2,6-dione, is an abundant compound present in coffee, food and drugs. It interacts with various pathways of which antagonism of adenosine receptors is the most significant but the other physiological pathways can be influenced by caffeine as well. Interaction with glutamate and dopamine neurotransmission pathways, competition with other substrates on cytochrome P450, non-competitive inhibition of acetylcholinesterase, blocking of nicotinic acetylcholine receptor and competitive inhibition of cyclic nucleotide phosphodiesterase can be mentioned. Because of caffeine availability in foods, beverages and drugs, it has practical relevance even if the effect is weak. Intake of coffee containing edibles for a long period or even for a substantial part of life makes caffeine ' s impact significant. Low acute and chronic toxicity of caffeine is another important specification. The discoveries from the last few years point to the fact that caffeine would interfere with the progression of some age-related neurodegenerative disorders like Alzheimer's and Parkinson's diseases and dementia with Lewy bodies. In this review article, the recent findings about caffeine ' s impact on neurodegenerative diseases are presented and important facts about the caffeine effect, including the substantial discoveries, are described.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mini-Reviews in Medicinal Chemistry
ISSN
1389-5575
e-ISSN
1875-5607
Volume of the periodical
22
Issue of the periodical within the volume
21
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
10
Pages from-to
2726-2735
UT code for WoS article
000864627500004
EID of the result in the Scopus database
2-s2.0-85138884775