Monitoring the Effect of Vaccination on Mumps Cases Complications in the Czech Republic - Surveillance Data 2013–2022

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F25%3A00563904" target="_blank" >RIV/60162694:G44__/25:00563904 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/24:43927597 RIV/75010330:_____/24:00014704

Result on the web

<a href="https://sciendo.com/journal/SJPH" target="_blank" >https://sciendo.com/journal/SJPH</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/sjph-2024-0027" target="_blank" >10.2478/sjph-2024-0027</a>

Result language

angličtina

Original language name

Monitoring the Effect of Vaccination on Mumps Cases Complications in the Czech Republic - Surveillance Data 2013–2022

Original language description

Introduction Mumps data were analysed to assess the effect of vaccination on mumps complications and hospitalisation. Methods The mumps cases reported to the Czech nationwide surveillance system from 2013 to 2022 were analysed using logistic regression with an odds ratio (aOR) adjusted for age, sex, year of onset and administrative region to measure the association between vaccination and complications or hospitalisation. Adjusted vaccine effectiveness (aVE) was calculated: aVE=(1-aOR)x100. Results A total of 11,913 mumps cases were reported, of which 6,885 (58%) were male. The median age of the study participants was 16 (range: 0–89 years). No complications occurred in 91% of patients. Mumps orchitis occurred in 633 (9%) male cases. A total of 946 (8%) patients required hospitalisation. The highest proportion of complications and hospitalisations was in the age group 35–44 years. Two doses of vaccine reduced statistically significantly the risk of any complications and of hospitalisation compared with unvaccinated patients: aOR 0.48 (95% CI: 0.37, 0.62), aVE of 52% (95% CI: 38, 63); and aOR 0.43 (95% CI: 0.33, 0.56), aVE of 57% (95% CI: 44, 67), respectively. Two doses showed statistically significant aVE 50% (95% CI: 32, 64) against orchitis, and 59% (95% CI: 23, 79) against meningitis. Among the two-dose recipients, the proportion of complications increased gradually with the time from the second dose. Conclusions Our findings demonstrated a protective effect of two-dose vaccination against mumps complications and hospitalisation for mumps. We recommend continuing routine childhood mumps vaccination and maintaining high MMR coverage in Czechia.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30304 - Public and environmental health

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Zdravstveno Varstvo

ISSN

0351-0026

e-ISSN

1854-2476

Volume of the periodical

63

Issue of the periodical within the volume

4

Country of publishing house

SI - SLOVENIA

Number of pages

9

Pages from-to

205-213

UT code for WoS article

001318535600003

EID of the result in the Scopus database

2-s2.0-85205468649