Strong antimicrobial activity of xanthohumol and other derivatives from hops (Humulus lupulus L.) on gut anaerobic bacteria
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60193697%3A_____%2F17%3AN0000038" target="_blank" >RIV/60193697:_____/17:N0000038 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/17:00481502 RIV/60162694:G44__/17:43889232 RIV/00216208:11130/17:10373203 RIV/00216208:11160/17:10373203 and 2 more
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1111/apm.12747" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1111/apm.12747</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/apm.12747" target="_blank" >10.1111/apm.12747</a>
Alternative languages
Result language
angličtina
Original language name
Strong antimicrobial activity of xanthohumol and other derivatives from hops (Humulus lupulus L.) on gut anaerobic bacteria
Original language description
Anaerobic bacteria, such as Bacteroides fragilis or Clostridium perfringens, are part of indigenous human flora. However, Clostridium difficile represents also an important causative agent of nosocomial infectious antibiotic-associated diarrhoea. Treatment of C.difficile infection is problematic, making it imperative to search for new compounds with antimicrobial properties. Hops (Humulus lupulus L.) contain substances with antibacterial properties. We tested antimicrobial activity of purified hop constituents humulone, lupulone and xanthohumol against anaerobic bacteria. The antimicrobial activity was established against B.fragilis, C.perfringens and C.difficile strains according to standard testing protocols (CLSI, EUCAST), and the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBC) were calculated. All C.difficile strains were toxigenic and clinically relevant, as they were isolated from patients with diarrhoea. Strongest antimicrobial effects were observed with xanthohumol showing MIC and MBC values of 15-107g/mL, which are close to those of conventional antibiotics in the strains of bacteria with increased resistance. Slightly higher MIC and MBC values were obtained with lupulone followed by higher values of humulone. Our study, thus, shows a potential of purified hop compounds, especially xanthohumol, as alternatives for treatment of infections caused by select anaerobic bacteria, namely nosocomial diarrhoea caused by resistant strains.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/GA14-10233S" target="_blank" >GA14-10233S: Humulus Lupulus L. - source of substances with antimicrobial effect</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta pathologica, microbiologica et immunologica Scandinavica
ISSN
0903-4641
e-ISSN
1600-0463
Volume of the periodical
125
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
1033-1038
UT code for WoS article
000413915600010
EID of the result in the Scopus database
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