Inhibitory effect of hop fractions against gram-positive multi-resistant bacteria. A pilot study.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60193697%3A_____%2F18%3AN0000036" target="_blank" >RIV/60193697:_____/18:N0000036 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/18:43889942 RIV/61989592:15110/18:73593424
Result on the web
<a href="http://biomed.papers.upol.cz/artkey/bio-201804-0005_inhibitory_effect_of_hop_fractions_against_gram-positive_multi-resistant_bacteria_a_pilot_study.php" target="_blank" >http://biomed.papers.upol.cz/artkey/bio-201804-0005_inhibitory_effect_of_hop_fractions_against_gram-positive_multi-resistant_bacteria_a_pilot_study.php</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2018.026" target="_blank" >10.5507/bp.2018.026</a>
Alternative languages
Result language
angličtina
Original language name
Inhibitory effect of hop fractions against gram-positive multi-resistant bacteria. A pilot study.
Original language description
Aim: Our research focused on the antimicrobial effects of purified hop (Humulus lupulus L.) fractions including α-bitter acids (humulones), β-bitter acids (lupulones) and xanthohumol, and a commercial CO2 hop extract of bitter acids against reference and multi-resistant strains of Gram-positive and Gram-negative bacteria and against selected yeast strains. Methods: In vitro testing of antimicrobial activity was performed according to standard testing protocols (EUCAST). The effects of hop extracts on bacterial/yeast strains at concentrations below MICs were also determined and the antimicrobial potential of hop extracts was compared with selected antibiotics using optical density measurement. Results: The fractions were effective not only against reference strains of Gram-positive bacteria but, more importantly, against their methicillin- and vancomycin-resistant variants. No antimicrobial effect was detected against Gram-negative bacterial strains. Among the tested substances, xanthohumol was identified as the hop fraction with the most potent antimicrobial properties. It was also found that hop substances exerted their antimicrobial effects at concentrations considerably lower than the determined MICs, with the strongest effect in case of α-bitter acids in enterococci. Conclusion: The search for and research of new compounds with antimicrobial properties represents a possible solution to the current global problem of bacterial resistance. Our data suggest a desirable activity of hop fractions against some multi-resistant bacterial strains. Thus, hops might find use as a source of potential antimicrobial agents applicable in both human and veterinary medicine.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/GA14-10233S" target="_blank" >GA14-10233S: Humulus Lupulus L. - source of substances with antimicrobial effect</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers
ISSN
1213-8118
e-ISSN
1804-7521
Volume of the periodical
162
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
276-283
UT code for WoS article
000457488200005
EID of the result in the Scopus database
2-s2.0-85057316219