Effect of Protein Kinase C Inhibitors on Porcine Oocyte Activation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F06%3A19117" target="_blank" >RIV/60460709:41210/06:19117 - isvavai.cz</a>
Alternative codes found
RIV/00027014:_____/06:#0000272
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Effect of Protein Kinase C Inhibitors on Porcine Oocyte Activation
Original language description
The effect of protein kinase C (PKC) inhibitors on porcine oocyte activation by calcium ionophore A23187 was studied. When the ionophore-treated oocytes were exposed to the effect of bisindolylmaleimide I, which inhibits calcium-dependent PKC isotypes and calcium-independent PKC isotypes, the portion of activated oocytes decreased. The inhibition of calcium dependent PKC isotypes did not prevent the action of the oocytes treated with calcium. The inhibitor of PKC-ä isotype, rottlerin, suppressed activation of the oocytes by calcium ionophopre On the basis of these results it can be supposed that PKC participates in the regulation of processes associated with oocyte activation. Calcium-dependent PKC sotypes do not seem to play any significant role in calcium activation. The activation seems to depend on the activity of the calcium-independent PKC-ä isoform.
Czech name
Vliv inhibitorů protein kinasy C na aktivaci prasečích oocytů
Czech description
The effect of protein kinase C (PKC) inhibitors on porcine oocyte activation by calcium ionophore A23187 was studied. When the ionophore-treated oocytes were exposed to the effect of bisindolylmaleimide I, which inhibits calcium-dependent PKC isotypes and calcium-independent PKC isotypes, the portion of activated oocytes decreased. The inhibition of calcium dependent PKC isotypes did not prevent the action of the oocytes treated with calcium. The inhibitor of PKC-ä isotype, rottlerin, suppressed activation of the oocytes by calcium ionophopre On the basis of these results it can be supposed that PKC participates in the regulation of processes associated with oocyte activation. Calcium-dependent PKC sotypes do not seem to play any significant role in calcium activation. The activation seems to depend on the activity of the calcium-independent PKC-ä isoform.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GG - Zootechnics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/QG50052" target="_blank" >QG50052: Reproductive biotechniques in pigs</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Experimental Zoology Part A
ISSN
1548-8969
e-ISSN
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Volume of the periodical
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Issue of the periodical within the volume
305
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
376-382
UT code for WoS article
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EID of the result in the Scopus database
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