In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F11%3A50668" target="_blank" >RIV/60460709:41210/11:50668 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41610/11:50668 RIV/00064203:_____/11:8928
Result on the web
<a href="http://dx.doi.org/10.1093/jac/dkr108" target="_blank" >http://dx.doi.org/10.1093/jac/dkr108</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/jac/dkr108" target="_blank" >10.1093/jac/dkr108</a>

Result language
angličtina
Original language name
In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus
Original language description
Objectives: In this study we examined the in vitro synergistic effect of baicalin, the flavone constituent of Scutellaria spp., in combinations with oxytetracycline and tetracycline on the growth of Staphylococcus aureus. Methods: The MICs were determined by the broth microdilution method and the effect of combinations was evaluated according to the sum of fractional inhibitory concentration indices (FICIs). Results: Synergistic activity (FICI?0.5) was observed for combinations of baicalin with oxytetracycline or tetracykline against 4 of 10 strains tested, whereas the baicalin/oxytetracycline combination possessed the strongest synergistic effect (FICI=0.418). Conclusions: Baicalin acts synergistically with oxytetracycline and tetracycline, enhancingits antimicrobial activity against S. aureus, including methicillin- and tetracycline-resistant strains.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GM - Food industry
OECD FORD branch
—

Project
<a href="/en/project/GD525%2F08%2FH060" target="_blank" >GD525/08/H060: Synbiotics and plant extracts in human and animal nutrition</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)