Potentiation of the in vitro Antistaphylococcal Effect of Oxacillin and Tetracycline by the Anti-Inflammatory Drug Diacetyl Rhein
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F14%3A69853" target="_blank" >RIV/60460709:41210/14:69853 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41340/14:69853
Result on the web
<a href="http://dx.doi.org/10.1159/000363730" target="_blank" >http://dx.doi.org/10.1159/000363730</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000363730" target="_blank" >10.1159/000363730</a>
Alternative languages
Result language
angličtina
Original language name
Potentiation of the in vitro Antistaphylococcal Effect of Oxacillin and Tetracycline by the Anti-Inflammatory Drug Diacetyl Rhein
Original language description
Background: The anti-inflammatory drug diacetyl rhein has been found to possess promising antistaphylococcal effects against various drug-resistant strains in our previous study. In the present work, we explored the in vitro combinatory interactions of diacetyl rhein with oxacillin and tetracycline against 13 standard strains and clinical isolates of Staphylococcus aureus, including those resistant to erythromycin, methicillin and tetracycline. Methods: Minimum inhibitory concentrations were determinedby broth microdilution assay, and the effects of combinations were evaluated according to the sum of fractional inhibitory concentrations (?FICs). Results: Synergistic or additive effects were observed against all S. aureus strains (?FIC 0.258?1), whereas diacetyl rhein - oxacillin appeared to be the most effective combination, synergistically inhibiting the growth of 4 strains tested. Conclusion: To our best knowledge, this is the first report on a synergistic antibacterial effect of di
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GM - Food industry
OECD FORD branch
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Result continuities
Project
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Continuities
O - Projekt operacniho programu
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CHEMOTHERAPY
ISSN
0009-3157
e-ISSN
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Volume of the periodical
59
Issue of the periodical within the volume
6
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
6
Pages from-to
447-452
UT code for WoS article
000341818900009
EID of the result in the Scopus database
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