In vitro Combinatory Antimicrobial Effect of Plumbagin with Oxacillin and Tetracycline against Staphylococcus aureus
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F15%3A66019" target="_blank" >RIV/60460709:41210/15:66019 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41340/15:66019
Result on the web
<a href="http://dx.doi.org/10.1002/ptr.5237" target="_blank" >http://dx.doi.org/10.1002/ptr.5237</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ptr.5237" target="_blank" >10.1002/ptr.5237</a>
Alternative languages
Result language
angličtina
Original language name
In vitro Combinatory Antimicrobial Effect of Plumbagin with Oxacillin and Tetracycline against Staphylococcus aureus
Original language description
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), a bicyclic naphthoquinone naturally distributed among Plumbago species, has been reported to have antimicrobial activity against a wide range of microorganisms. In this study, plumbagin was examined forits combinatory antimicrobial effect with tetracycline or oxacillin against nine strains of Staphylococcus aureus, including its methicillin- and multidrug-resistant strains.Minimum inhibitory concentrations were determined through the broth microdilution method, whereas the combinatory effect was evaluated according to the sum of fractional inhibitory concentration (?FIC) indices. Additive interactions were obtained for both combinations against most of the strains tested. Synergy was obtained for combination with oxacillin against two out of seven strains (?FIC range 0.273?0.281), both were methicillin resistant. Our results proved plumbagin as a compound suitable for anti-Staphylococcal combinatory testing. Moreover, to the best of o
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GM - Food industry
OECD FORD branch
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Result continuities
Project
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Continuities
O - Projekt operacniho programu
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PHYTOTHERAPY RESEARCH
ISSN
0951-418X
e-ISSN
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Volume of the periodical
29
Issue of the periodical within the volume
1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
4
Pages from-to
144-147
UT code for WoS article
000348060300022
EID of the result in the Scopus database
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