Progressive rod-cone degeneration (PRCD) in selected dog breeds and variability in its phenotypic expression

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F11%3A50725" target="_blank" >RIV/60460709:41210/11:50725 - isvavai.cz</a>

Alternative codes found

RIV/67985904:_____/11:00368230

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Progressive rod-cone degeneration (PRCD) in selected dog breeds and variability in its phenotypic expression

Original language description

Progressive rod-cone degeneration (PRCD) is a late onset autosomal photoreceptor degeneration found in canines. PRCD in canines is homologous to one form of retinitis pigmentosa (RP) found in humans and displays phenotypic similarity as well as having the identical caustive mutation. The PRCD gene was mapped to the centromeric region of canine chromosome 9 (CFA9). We report here a population study of 699 dogs of the following breeds and the following frequencies of the disease-causing mutation: AmericanCocker Spaniel (0.09), English Cocker S. (0.34), Eng. Springer S. (0.00), Welsh Springer S. (0.00), Golden Retriever (0.00) etc. The disease result in complete blindness in the affected individual in almost every case. The time of onset and disease progression varies between dog breeds as well as between individuals. A modifier gene is likely to segregate in genomic proximity to the PRCD gene and may influence phenotypic expression.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Veterinarni Medicina

ISSN

0375-8427

e-ISSN

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Volume of the periodical

56

Issue of the periodical within the volume

5

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

243-247

UT code for WoS article

000291939600004

EID of the result in the Scopus database

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