Effect of zearalenone on reproductive parameters and expression ofselected testicular genes in miceE

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F14%3A64333" target="_blank" >RIV/60460709:41210/14:64333 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/14:00434230

Result on the web

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DOI - Digital Object Identifier

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Result language

čeština

Original language name

Effect of zearalenone on reproductive parameters and expression ofselected testicular genes in mice

Original language description

We tested the effect of two different concentrations (150 ?g/l and 0.15 ?g/l) of mycotoxin zearalenone(ZEA) on the reproductive parameters and expression of testicular genes in male mice. In adult males, noreduction of body or reproductive organ weight was observed, and the seminiferous tubules were mor-phologically normal with ongoing spermatogenesis. However, we found decreased sperm concentration,increase of morphologically abnormal spermatozoa and increased binding of apoptotic marker annexinV. Thisstudy was also focused on the evaluation of gene expression profiles of 28 genes playing importantroles during the processes occurring in the testicular tissue. We detected changes in the expression ofgenes important for proper spermatogenesis. Surprisingly, we observed a stronger effect after exposureto the lower dose of ZEA.

Czech name

Effect of zearalenone on reproductive parameters and expression ofselected testicular genes in mice

Czech description

We tested the effect of two different concentrations (150 ?g/l and 0.15 ?g/l) of mycotoxin zearalenone(ZEA) on the reproductive parameters and expression of testicular genes in male mice. In adult males, noreduction of body or reproductive organ weight was observed, and the seminiferous tubules were mor-phologically normal with ongoing spermatogenesis. However, we found decreased sperm concentration,increase of morphologically abnormal spermatozoa and increased binding of apoptotic marker annexinV. Thisstudy was also focused on the evaluation of gene expression profiles of 28 genes playing importantroles during the processes occurring in the testicular tissue. We detected changes in the expression ofgenes important for proper spermatogenesis. Surprisingly, we observed a stronger effect after exposureto the lower dose of ZEA.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GG - Zootechnics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

REPRODUCTIVE TOXICOLOGY

ISSN

0890-6238

e-ISSN

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Volume of the periodical

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Issue of the periodical within the volume

45

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

11

Pages from-to

20-30

UT code for WoS article

000336415800004

EID of the result in the Scopus database

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