Epigenome Modification and Ubiquitin-Dependent Proteolysis During Pronuclear Development of the Mammalian Zygote: Animal Models to Study Pronuclear Development
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F17%3A67960" target="_blank" >RIV/60460709:41210/17:67960 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Epigenome Modification and Ubiquitin-Dependent Proteolysis During Pronuclear Development of the Mammalian Zygote: Animal Models to Study Pronuclear Development
Original language description
In vitro fertilization (IVF) and embryo culture is a key approach for study of early development in mammals, with application in human assisted reproductive therapy (ART) and livestock embryo transfer (ET). Persistent issue of current assisted reproduction is decreased efficiency of embryo production compared to in vivo conditions. Beside DNA methylation, adequate insertion and post-translational modifications of DNA-associated histones determine zygote genome stability, parental gene expression inheritance and proper formation of zygotic pronuclei and blastomere nuclei. Subsequent to the formation of maternal and paternal pronuclei, the timing of nucleolus reconstitution and reactivation, and embryonic genome reprogramming is species specific. Such DNA and histone modifications during early development are regulated by ooplasmic factors including DNA methyltransferases, histone methyltransferases and histone deacetylases, as well as by the ubiquitin-proteasome system (UPS), a significant epigenome c
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10604 - Reproductive biology (medical aspects to be 3)
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Animal Models and Human Reproduction: Cell and Molecular Approaches with Reference to Human Reproduction
ISBN
9781118881422
Number of pages of the result
16
Pages from-to
435-450
Number of pages of the book
600
Publisher name
Willey & Sons
Place of publication
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UT code for WoS chapter
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