Bisphenol S negatively affects the meiotic maturation of pig oocytes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F17%3A73469" target="_blank" >RIV/60460709:41210/17:73469 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1038/s41598-017-00570-5" target="_blank" >http://dx.doi.org/10.1038/s41598-017-00570-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-017-00570-5" target="_blank" >10.1038/s41598-017-00570-5</a>

Result language

angličtina

Original language name

Bisphenol S negatively affects the meiotic maturation of pig oocytes

Original language description

Bisphenol A (BPA), a chemical component of plastics, is a widely distributed environmental pollutant and contaminant of water, air, and food that negatively impacts human health. Concerns regarding BPA have led to the use of BPA-free alternatives, one of which is bisphenol S (BPS). However, the effects of BPS are not well characterized, and its specific effects on reproduction and fertility remain unknown. It is therefore necessary to evaluate any effects of BPS on mammalian oocytes. The present study is the first to demonstrate the markedly negative effects of BPS on pig oocyte maturation in vitro, even at doses lower than those humans are exposed to in the environment. Our results demonstrate (1) an effect of BPS on the course of the meiotic cell cycle, (2) the failure of tubulin fibre formation, which controls proper chromosome movement, (3) changes in the supply of maternal mRNA, (4) changes in the protein amounts and distribution of oestrogen receptors alpha and beta and of aromatase, a

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/QJ1510138" target="_blank" >QJ1510138: Innovation of reproductive biotechiques in farm animals</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

—

Volume of the periodical

7

Issue of the periodical within the volume

N

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

1-11

UT code for WoS article

000397528600017

EID of the result in the Scopus database

2-s2.0-85016836270