Aminoguanidine protects boar spermatozoa against the deleterious effects of oxidative stress

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F18%3A77313" target="_blank" >RIV/60460709:41210/18:77313 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3390/pharmaceutics10040212" target="_blank" >http://dx.doi.org/10.3390/pharmaceutics10040212</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/pharmaceutics10040212" target="_blank" >10.3390/pharmaceutics10040212</a>

Result language

angličtina

Original language name

Aminoguanidine protects boar spermatozoa against the deleterious effects of oxidative stress

Original language description

Aminoguanidine is a selective inhibitor of the inducible nitric oxide synthase (iNOS) and a scavenger of reactive oxygen species (ROS). Numerous studies have shown the antioxidant properties of aminoguanidine in several cell lines, but the in vitro effects of this compound on spermatozoa under oxidative stress are unknown. In this study, we tested the hypothesis that aminoguanidine may protect against the detrimental effects of oxidative stress in boar spermatozoa. For this purpose, sperm samples were incubated with a ROS generating system (Fe/ascorbate) with or without aminoguanidine supplementation (10, 1, and 0,1 mM). Our results show that aminoguanidine has powerful antioxidant capacity and protects boar spermatozoa against the deleterious effects of oxidative stress. After 2 h and 3,5 h of sperm incubation, the samples treated with aminoguanidine showed a significant increase in sperm velocity, plasma membrane and acrosome integrity together with a reduced lipid peroxidation in comparison with c

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pharmaceutics

ISSN

1999-4923

e-ISSN

—

Volume of the periodical

10

Issue of the periodical within the volume

4

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

1-14

UT code for WoS article

000455853800050

EID of the result in the Scopus database

2-s2.0-85056584289