The effect of zinc and/or vitamin E supplementation on biochemical parameters of selenium-overdosed rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F18%3A77959" target="_blank" >RIV/60460709:41210/18:77959 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/18:00502285 RIV/61388971:_____/18:00502285 RIV/60461373:22330/18:43916206 RIV/60461373:22340/18:43916206
Result on the web
<a href="http://dx.doi.org/10.24425/124312" target="_blank" >http://dx.doi.org/10.24425/124312</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.24425/124312" target="_blank" >10.24425/124312</a>

Result language
angličtina
Original language name
The effect of zinc and/or vitamin E supplementation on biochemical parameters of selenium-overdosed rats
Original language description
The normotensive (Wistar) and spontaneously hypertensive (SHR) rats were examined to assess the response of the organism to selenium (Se) overdose. Moreover, the effect of zinc (Zn) and vitamin E, i.e. dietary components interacting in many biochemical processes with Se, on the Se uptake was evaluated. The control group was fed an untreated diet, and the diets of two other groups were overdosed with Se in the form of sodium selenite (9 mg/kg) and supplemented with Zn (13 mg/kg). Two experimental groups were fed a diet supplemented with Zn (13 mg/kg) and Se at an adequate level (0,009 mg/kg), a half of the animals was supplemented with vitamin E. The results showed significant differences in the Se contents between the rat strains in case of Se-overdosed groups, where in the liver and kidney tissue Se contents of SHR rats exceeded 3- and 7-fold the normotensive ones. The Se uptake was altered by the vitamin E, no effect of Zn was observed. Activities of antioxidant enzymes were determined in the anima
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
40301 - Veterinary science

Project
<a href="/en/project/GA13-04580S" target="_blank" >GA13-04580S: Transformation and speciation of selenium in the food chain: the effect of selenium fortified diet</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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