Serine proteases in schistosomes and other trematodes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F18%3A78055" target="_blank" >RIV/60460709:41210/18:78055 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/18:00490315
Result on the web
<a href="http://dx.doi.org/10.1016/j.ijpara.2018.01.001" target="_blank" >http://dx.doi.org/10.1016/j.ijpara.2018.01.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpara.2018.01.001" target="_blank" >10.1016/j.ijpara.2018.01.001</a>
Alternative languages
Result language
angličtina
Original language name
Serine proteases in schistosomes and other trematodes
Original language description
Trematodes, also known as flukes, are phylogenetically ancient parasitic organisms. Due to their importance as human and veterinary parasites, their proteins have been investigated extensively as drug and vaccine targets. Among those, proteases, as crucial enzymes for parasite survival, are considered candidate molecules for anti-parasitic interventions. Surprisingly however, trematode serine proteases, in comparison with other groups of proteases, are largely neglected. Genes encoding serine proteases have been identified in trematode genomes in significant abundance, but the biological roles and biochemical functions of these proteases are poorly understood. However, increasing volumes of genomic and proteomic studies, and accumulated experimental evidence, indicate that this class of proteases plays a substantial role in host-parasite interactions and parasite survival. Here, we discuss in detail serine proteases at genomic and protein levels, and their known or hypothetical functions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30310 - Parasitology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
INTERNATIONAL JOURNAL FOR PARASITOLOGY
ISSN
0020-7519
e-ISSN
0020-7519
Volume of the periodical
48
Issue of the periodical within the volume
5
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
12
Pages from-to
333-344
UT code for WoS article
000430889100003
EID of the result in the Scopus database
2-s2.0-85042653239