Metabolism of cis-and trans-Resveratrol and Dihydroresveratrol in an Intestinal Epithelial Model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F20%3A82414" target="_blank" >RIV/60460709:41210/20:82414 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14160/20:00118238 RIV/62157124:16370/20:43878580
Result on the web
<a href="https://www.mdpi.com/2072-6643/12/3/595" target="_blank" >https://www.mdpi.com/2072-6643/12/3/595</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/nu12030595" target="_blank" >10.3390/nu12030595</a>
Alternative languages
Result language
angličtina
Original language name
Metabolism of cis-and trans-Resveratrol and Dihydroresveratrol in an Intestinal Epithelial Model
Original language description
Trans-resveratrol, a well-known plant phenolic compound, has been intensively investigated due to its association with the so-called French paradox. However, despite its high pharmacological potential, trans-resveratrol has shown relatively low bioavailability. Trans-resveratrol is intensively metabolized in the intestine and liver, yielding metabolites that may be responsible for its high bioactivity. The aim of this study was to investigate and compare the metabolism of trans-resveratrol (tRes), cis-resveratrol (cRes) and dihydroresveratrol (dhRes) in an in vitro epithelial model using Caco-2 cell lines. Obtained metabolites of tRes, cRes and dhRes were analyzed by LC/MS Q-TOF, and significant differences in the metabolism of each compound were observed. The majority of tRes was transported unchanged through the Caco-2 cells, while cRes was mostly metabolized. The main metabolite of both cis- and trans-resveratrol observed as a result of colon microbial metabolism, dhRes, was metabolized almost com
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30308 - Nutrition, Dietetics
Result continuities
Project
<a href="/en/project/GA16-07193S" target="_blank" >GA16-07193S: Anti-inflammatory activity of selected stilbenoids, 2-arylbenzofuranes and their metabolites</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nutrients
ISSN
2072-6643
e-ISSN
2072-6643
Volume of the periodical
12
Issue of the periodical within the volume
3
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
1-11
UT code for WoS article
000531831000004
EID of the result in the Scopus database
2-s2.0-85079868760