Does the in vitro egg hatch test predict the failure of benzimidazole treatment in Haemonchus contortus
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F21%3A85755" target="_blank" >RIV/60460709:41210/21:85755 - isvavai.cz</a>
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375488/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375488/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1051/parasite/2021059" target="_blank" >10.1051/parasite/2021059</a>
Alternative languages
Result language
angličtina
Original language name
Does the in vitro egg hatch test predict the failure of benzimidazole treatment in Haemonchus contortus
Original language description
Considerable research has been directed towards optimising in vitro tests that can diagnose resistance in pre-parasitic stages of parasites. The objective of this study was to compare the in vivo faecal egg count reduction test (FECRT), the in vitro egg hatch test (EHT), and the molecular determination of the frequency of a codon 200 allele of beta-tubulin isotype 1 associated with benzimidazole resistance in larval stages of Haemonchus contortus obtained from infected goats. Animals were infected with composite infective doses representing 10, 20, 30, 40, 60, and 80% resistant alleles. Faecal samples for the EHT were collected on 28, 33, and 35 days post-infection. The results of the in vivo FECRT indicated that albendazole treatment reduced infections consisting of composite doses of 10, 20, 30, 40, 60, and 80% larvae of the resistant isolate by 91,3, 78,0, 63,3, 48,4, 36,5, and 41,4%, respectively. The drug concentration at which 50% of the eggs were prevented from developing hatching larvae (ED50
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Parasite - Journal de la Societe Francaise de Parasitologie
ISSN
1252-607X
e-ISSN
1776-1042
Volume of the periodical
28
Issue of the periodical within the volume
August 2021
Country of publishing house
FR - FRANCE
Number of pages
6
Pages from-to
0-0
UT code for WoS article
000686297600001
EID of the result in the Scopus database
2-s2.0-85113488802