Bifidogenic effect of prebiotics: a nutritional strategy for gut microbiome modulation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F25%3A101900" target="_blank" >RIV/60460709:41210/25:101900 - isvavai.cz</a>

Result on the web

<a href="https://conferences.imeko.org/event/12/attachments/907/1830/IMEKOFOODS25-Book%20of%20Abstracts.pdf" target="_blank" >https://conferences.imeko.org/event/12/attachments/907/1830/IMEKOFOODS25-Book%20of%20Abstracts.pdf</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Bifidogenic effect of prebiotics: a nutritional strategy for gut microbiome modulation

Original language description

Bifidobacteria are an important group of commensal bacteria within the human gut microbiota and are considered among the dominant microbial taxa in infants. Although their abundance tends to decline with the ageing of the host organism, their presence in the intestine remains associated with a range of beneficial effects that support human health. As saccharolytic anaerobes, bifidobacteria primarily colonise the distal parts of the gastrointestinal tract, where they produce short-chain fatty acids, antimicrobial compounds, and vitamins. Their metabolic activity involves cross-feeding interactions with other microbes, inhibition of pathogens, and modulation of the host immune system. To support bifidobacterial persistence, various strategies are being explored. One promising approach is the use of prebiotic substances, which may be incorporated into the diet either naturally or through dietary supplementation, in both endogenous and dietary forms. These substances (typically carbohydrate-based) are selectively utilised by host microorganisms and confer health benefits at various sites of action. To be classified as prebiotics, they must meet several essential criteria as defined by the International Scientific Association for Probiotics and Prebiotics (ISAPP). Common examples include human milk oligosaccharides (HMOs), galacto-, fructo-, xylo-, soybean-, pectic-, and mannan-oligosaccharides. In recent years, additional candidates such as novel plant-derived oligosaccharides, polyphenols, and ß-glucans have also gained attention. Bifidogenic prebiotics positively modulate bifidobacterial abundance and play an increasing role in the modern nutrition of the human population. Their inclusion in the daily diet may contribute to disease prevention, enhancement of immune function, improved digestion, and overall health maintenance. Nevertheless, the bifidogenic response to prebiotics may vary depending on the host’s age and microbial background, both of which must be considered. Thus, the ongoing search for novel prebiotic compounds with selectivity for typical bifidobacterial species is desirable and holds great promise for targeted modulation and long-term maintenance of gut microbiota homeostasis. Acknowledgements: This work was supported by a grant LUAUS23014 from the MEYS, Czech Republic and by the METROFOOD-CZ research infrastructure project (MEYS Grant No: LM2023064) including access to its facilities.

Czech name

—

Czech description

—

Type

O - Miscellaneous

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

<a href="/en/project/LUAUS23014" target="_blank" >LUAUS23014: Primary microbiota and its importance for the health status of premature infants: A study on a gnotobiotic piglet model</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů