Modulation of newborn and Infant microbiota with prebiotics and probiotics

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F25%3A101901" target="_blank" >RIV/60460709:41210/25:101901 - isvavai.cz</a>

Result on the web

<a href="https://conferences.imeko.org/event/12/attachments/907/1830/IMEKOFOODS25-Book%20of%20Abstracts.pdf" target="_blank" >https://conferences.imeko.org/event/12/attachments/907/1830/IMEKOFOODS25-Book%20of%20Abstracts.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Modulation of newborn and Infant microbiota with prebiotics and probiotics

Original language description

Prebiotics and probiotics are now quite established terms that are associated with a beneficial effect on human health. But since when do they naturally become a part of our diet? Since when should we consider their supplementation? Moreover, it is necessary to consider not only their potential independent or synbiotic benefits, but also the interaction at the level of the host microbiota, which may be very individual. The aim of our work is to focus on the choice of suitable prebiotics and probiotics during the initial colonization of the newborn's intestine, or rather the infant, with regard to gestational age, mode of delivery, and the initial period of nutrition, i.e., liquid food diet. Therefore, we longitudinally monitored an infant, combining both cultivation and molecular genetic approaches, to determine microbiota development and evaluate prebiotic and probiotic interventions. It is desirable to underscore the importance of targeted prebiotic and probiotic interventions during critical developmental periods, not only for their direct effects on specific microbial populations but also for their potential to modulate overall microbial interactions. Human milk is a unique source of oligosaccharides, which, however, despite the best efforts, cannot be fully synthesized, and therefore, we are looking for alternatives whose use has clear justifications. As well as including probiotics in the diet of newborns born out of right gestational age, surgically instead of vaginally, or whose microbial colonization is not standard and suffers e.g., from colic. These are just a few examples for considering the supplementation of prebiotics and probiotics. Moreover, the effect does not end with their application; it extends to the further development of the individual. Our findings highlight the importance of considering probiotic and prebiotic supplementation in newborns whose early microbial colonization may be suboptimal, such as those born via cesarean section, prematurely, or not breastfed. While breastfeeding remains the gold standard due to its unique oligosaccharide content, our results demonstrate that targeted microbiota modulation can have meaningful and lasting effects on infant development. Acknowledgements: This work was supported by a grant LUAUS23014 from the MEYS, Czech Republic and by the METROFOOD-CZ research infrastructure project (MEYS Grant No: LM2023064) including access to its facilities.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

10606 - Microbiology

Project

<a href="/en/project/LUAUS23014" target="_blank" >LUAUS23014: Primary microbiota and its importance for the health status of premature infants: A study on a gnotobiotic piglet model</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů