Assessment of the synbiotic properites of human milk oligosaccharides and Bifidobacterium longum subsp infantis in vitro and in humanised mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F17%3A73599" target="_blank" >RIV/60460709:41210/17:73599 - isvavai.cz</a>

Alternative codes found

RIV/61388971:_____/17:00475173

Result on the web

<a href="http://dx.doi.org/10.3920/BM2016.0138" target="_blank" >http://dx.doi.org/10.3920/BM2016.0138</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3920/BM2016.0138" target="_blank" >10.3920/BM2016.0138</a>

Result language

angličtina

Original language name

Assessment of the synbiotic properites of human milk oligosaccharides and Bifidobacterium longum subsp infantis in vitro and in humanised mice

Original language description

The mode of delivery plays a crucial role in infant gastrointestinal tract colonisation, which in the case of caesarean section is characterised by the presence of clostridia and low bifidobacterial counts. Gut colonisation can be modified by probiotics, prebiotics or synbiotics. Human milk oligosaccharides HMOs are infant prebiotics that show a bifidogenic effect. Moreover, genome sequencing of Bifidobacterium longum subsp. infantis within the infant microbiome revealed adaptations for milk utilisation. This study aimed to evaluate the synbiotic effect of B. longum subsp. infantis, HMOs and human milk HM both in vitro and in vivo in a humanised mouse model in the presence of faecal microbiota from infants born by caesarean section. The combination of B. longum and HMOs or HM reduced the clostridia and G bacteria counts both in vitro and in vivo. The bifidobacterial population in vitro significantly increased and produce high concentrations of acetate and lactate. In vitro competition assays confirme

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

<a href="/en/project/GA15-07268S" target="_blank" >GA15-07268S: Gut microbiota and neuroendocrine regulatory pathways during stress</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Beneficial Microbes

ISSN

1876-2883

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

281-289

UT code for WoS article

000400167600013

EID of the result in the Scopus database

2-s2.0-85018245854