Chemical characterization and encapsulation of Ganoderma pfeifferi extract with cytotoxic properties
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F25%3A103051" target="_blank" >RIV/60460709:41210/25:103051 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.3389/fphar.2025.1526502" target="_blank" >https://doi.org/10.3389/fphar.2025.1526502</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fphar.2025.1526502" target="_blank" >10.3389/fphar.2025.1526502</a>
Alternative languages
Result language
angličtina
Original language name
Chemical characterization and encapsulation of Ganoderma pfeifferi extract with cytotoxic properties
Original language description
Mushrooms of the genus Ganoderma are known for diverse biological activities, demonstrated both traditionally and experimentally. Their secondary metabolites have shown cytotoxic potential across different cancer cell lines. Besides exploration of the most active components in different species or genotypes, new formulation techniques are in development. In recent years, there has been a growing interest in the use of nanomaterials because of significant potential for pharmacology applications as substance carriers. Applying nanoparticles may enhance the medicinal effect of the mushroom substances. This study investigated the cytotoxic properties of Ganoderma species methanolic extracts against the HeLa cancer cell line. Notably, the extract obtained from Ganoderma pfeifferi demonstrated the highest activity and was further used for encapsulation within synthesized mesoporous silica nanoparticles MCM-41. Subsequently, the cytotoxic effect of the loaded MCM-41 to the free form of extract was compared. The obtained results indicate successful encapsulation, and similar activity comparing encapsulated form to free extracts (IC50 16.6 µg/mL and 20.5 µg/mL, respectively). In addition, the four unique compounds were identified as applanoxidic acid A, applanoxidic acid G, ganoderone A, and ganoderone B in the G. pfeifferi. This study is an essential prerequisite for further steps like nanoparticle functionalization for sustained or on-command delivery of these natural extracts.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20601 - Medical engineering
Result continuities
Project
<a href="/en/project/QK1910209" target="_blank" >QK1910209: Research and development of the medicinal mushroom production in the Czech Republic and their innovative application in functional foods</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Pharmacology
ISSN
1663-9812
e-ISSN
1663-9812
Volume of the periodical
16
Issue of the periodical within the volume
neuvedeno
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
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UT code for WoS article
001414030000001
EID of the result in the Scopus database
2-s2.0-85216971067