An Ixodes scapularis Protein Disulfide Isomerase Contributes to Borrelia burgdorferi Colonization of the Vector.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41340%2F20%3A85197" target="_blank" >RIV/60460709:41340/20:85197 - isvavai.cz</a>
Result on the web
<a href="https://iai.asm.org/content/88/12/e00426-20" target="_blank" >https://iai.asm.org/content/88/12/e00426-20</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/IAI.00426-20" target="_blank" >10.1128/IAI.00426-20</a>
Alternative languages
Result language
angličtina
Original language name
An Ixodes scapularis Protein Disulfide Isomerase Contributes to Borrelia burgdorferi Colonization of the Vector.
Original language description
Borrelia burgdorferi causes Lyme disease, the most common tick transmitted illness in North America. When Ixodes scapularis feed on an infected vertebrate host, spirochetes enter the tick gut along with the bloodmeal and colonize the vector. Here, we show that a secreted tick protein, I. scapularis protein disulfide isomerase A3 (IsPDIA3), enhances B. burgdorferi colonization of the tick gut. I. scapularis ticks in which ispdiA3 has been knocked down using RNA interference have decreased spirochete colonization of the tick gut after engorging on B. burgdorferi-infected mice. Moreover, administration of IsPDIA3 antiserum to B. burgdorferi infected mice reduced the ability of spirochetes to colonize the tick when feeding on these animals. We show that IsPDIA3 modulates inflammatory responses at the tick bite site, potentially facilitating spirochete survival at the vector host interface as it exits the vertebrate host to enter the tick gut. These data provide functional insights into the complex intera
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
INFECTION AND IMMUNITY
ISSN
0019-9567
e-ISSN
1098-5522
Volume of the periodical
88
Issue of the periodical within the volume
12
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
17
Pages from-to
1-17
UT code for WoS article
000591527300017
EID of the result in the Scopus database
2-s2.0-85096347815