Synthesis of 3-(2-Hydroxy-1-phenylethyl)- and 3-(2-Hydroxy-2-phenylethyl)adenine, DNA Adducts Derived from Styrene
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F08%3A00020022" target="_blank" >RIV/60461373:22310/08:00020022 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Synthesis of 3-(2-Hydroxy-1-phenylethyl)- and 3-(2-Hydroxy-2-phenylethyl)adenine, DNA Adducts Derived from Styrene
Original language description
3-(2-Hydroxy-2-phenylethyl)- and 3-(2-hydroxy-1-phenylethyl)adenine, DNA adducts derived from styrene, along with their 9-substituted analogues were prepared by alkylation of 8-bromoadenine with corresponding allyl-protected bromohydrins followed by a new deallylation procedure using tetrakis(triphenylphosphine)palladium catalyzed reductive cleavage by poly(methylhydrosiloxane) in the presence of p-toluenesulphonic acid. This novel procedure proved to be useful for purine derivatives, which were resistant to other deallylation protocols. Structure of positional isomers was assigned using 2D NMR experiments HMBC and HMQC.
Czech name
Syntéza 3-(1-fenyl-2-hydroxyethyl)- a 3-(2-fenyl-2-hydroxyethyl)adeninu, DNA aduktů odvozených od styrenu
Czech description
3-(1-Fenyl-2-hydroxyethyl)- a 3-(2-fenyl-2-hydroxyethyl)adenin byly připraveny spolu s příslušnými 9-substituovanými adeniny alkylací 8-bromadeninu s následnou debromací a odchráněným. Připravené 3-substituované adeniny jsou pravděpodobnými DNA adukty odvozenými od styrenu a budou použity jako analytické standardy pro vývoj metod biologického monitorování exposice styrenu.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Heterocyclic Chemistry
ISSN
0022-152X
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
May-June
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
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UT code for WoS article
000255967700025
EID of the result in the Scopus database
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