Synthesis and Characterization of Styrene Oxide Adducts with Cysteine, Histidine, and Lysine in Human Globin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F07%3A00018504" target="_blank" >RIV/60461373:22310/07:00018504 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Synthesis and Characterization of Styrene Oxide Adducts with Cysteine, Histidine, and Lysine in Human Globin
Original language description
Synthesis of styrene 7,8-oxide (SO) adducts with cysteine, lysine and histidine is described. S-(2-hydroxy-1-phenylethyl)cysteine and S-(2-hydroxy-2-phenylethyl)cysteine were prepared by direct alkylation of cysteine with (R)-SO or (S)-SO enantiomers andisolated by semi-preparative HPLC. To obtain SO adducts with lysine and histidine, N?-Boc protected lysine and histidine derivatives were alkylated with pure SO enantiomers. Deprotection of the Boc group afforded corresponding derivatives. Pure N?-(2-hydroxy-1-phenylethyl)lysine, N?-(2-hydroxy-2-phenylethyl)lysine, or N?-(2-hydroxy-1-phenylethyl)histidine, N?-(2-hydroxy-2-phenylethyl)histidine, N?-(2-hydroxy-1-phenylethyl)histidine, and N?-(2-hydroxy-2-phenylethyl)histidine isomers were isolated by semipreparative HPLC. Structural assignments of these isomers were based on the NMR techniques. The isomers were used to assign the SO adducts in globin incubated with SO in vitro. Deuterated analogues of the SO adducts
Czech name
Synthesa a charakterisace aduktů styrenoxidu s cysteinem, histidinem a lysinem v lidském globinu.
Czech description
Práce popisuje synthesu aduktů styren-7,8-oxidu s cysteinem, lysinem a histidinem a jejich analysu v lidském globinu, který reagoval in vitro se styrenoxidem.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chem. Res. Toxicol.
ISSN
0893-228X
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
1442-1452
UT code for WoS article
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EID of the result in the Scopus database
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