Preparation of cysteine adducts by regioselective ring-opening reactions of phenyloxirane

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F15%3A43899855" target="_blank" >RIV/60461373:22310/15:43899855 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1515/hc-2015-0042" target="_blank" >http://dx.doi.org/10.1515/hc-2015-0042</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/hc-2015-0042" target="_blank" >10.1515/hc-2015-0042</a>

Result language
angličtina
Original language name
Preparation of cysteine adducts by regioselective ring-opening reactions of phenyloxirane
Original language description
Regio-selective ring opening reactions of the phenyloxirane ring by protected cysteine are described, which enabled synthesis of pure regio-isomeric cysteine adducts. The reaction catalysed by tris (pentafluorophenyl)borane afforded pure S-(2-hydroxy-1-phenylethyl)cysteine (alpha-adduct), whereas in the presence of tetrabutylammonium fluoride S-(2-hydroxy-2-phenylethyl)cysteine (beta-adduct) was formed predominantly. These products are needed for biological monitoring studies on the protein adducts formed from styrene.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/NT13401" target="_blank" >NT13401: Degradation products of protein adducts in urine as a new type of biomarkers in toxicology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)