Excretion of urinary N7 guanine and N3 adenine DNA adducts in mice after inhalation of styrene

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F09%3A00022821" target="_blank" >RIV/60461373:22310/09:00022821 - isvavai.cz</a>

Alternative codes found

RIV/75010330:_____/09:00008406

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Excretion of urinary N7 guanine and N3 adenine DNA adducts in mice after inhalation of styrene

Original language description

New urinary adenine adducts, 3-(2-hydroxy-1-phenylethyl)adenine (N3alphaA), 3-(2-hydroxy-2-phenylethyl)adenine (N3betaA), were found in the urine of mice exposed to styrene vapour. These styrene 7,8-oxide derived adenine adducts as well as previously identified guanine adducts, 7-(2-hydroxy-1-phenylethyl)guanine (N7alphaG) and 7-(2-hydroxy-2-phenylethyl)guanine (N7betaG) were quantified by HPLC-ESI-MS2 and the excretion profile during and after a repeated exposure to 600 or 1200 mg/m3 of styrene for 10consecutive days (6 h/day) was determined. The excretion was dose dependent. Total N3 adenine adducts (N3alphaA + N3betaA) excreted amounted to nearly 0.8 10-5 % of the absorbed dose while urinary N7 guanine adducts (N7aplhaG + N7betaG) amounted to nearly 1.4 10-5 % of the dose. No accumulation of the adducts was observed. Due to rapid depurination from the DNA, the excretion of both N3 adenine and N7 guanine adducts ceased shortly after finishing the exposure. Both N3 adenine and N7 gua

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/GA203%2F06%2F0888" target="_blank" >GA203/06/0888: N7 Substituted guanines for early diagnostics of DNA damage; development of synthetic and analytical methods</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology Letters

ISSN

0378-4274

e-ISSN

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Volume of the periodical

184

Issue of the periodical within the volume

1

Country of publishing house

IE - IRELAND

Number of pages

5

Pages from-to

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UT code for WoS article

000262544400006

EID of the result in the Scopus database

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