Phenyl(hydroxyethyl)guanines

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F03%3A00008200" target="_blank" >RIV/60461373:22310/03:00008200 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22640/03:00008200
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Phenyl(hydroxyethyl)guanines
Original language description
Phenyl(hydroxy)ethylguanines, in particular 7-(2-hydroxy-1-phenylethyl)guanine and 7-(2-hydroxy-2-phenylethyl)guanine, are important markers of exposure to styrene as well as indicators of DNA damage caused by styrene 7,8-oxide, a styrene metabolite. Animproved synthetic procedure leading to these compounds has been developed. As a rule, the alkylation reactions of guanine and guanine derivatives are rather unselective. The selectivity of alkylation was improved by using 7-methyl-10-oxo-9,10-dihydropyrimido[1,2-a]purine as a protected guanine compound, and allyl-protected bromohydrins as synthetic equivalents of styrene 7,8-oxide.
Czech name
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Czech description
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Project
<a href="/en/project/GA310%2F03%2F0437" target="_blank" >GA310/03/0437: New aspects in understanding styrene genotoxicity: the role of DNA repair,new reactive metabolites and secondary oxidative stress</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
10th Blue Danube Symposium on Heterocyclic Chemistry
ISBN
80-227-1938-2
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
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Publisher name
10th Blue Danube Symposium on Heterocyclic Chemistry
Place of publication
Bratislava
Event location
Vídeň, Rakousko
Event date
Sep 3, 2003
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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