Syntheses of 7-(2-hydroxy-1-phenylethyl)- and 7-(2-hydroxy-2-phenylethyl)guanine, DNA adducts derived from styrene 7,8-oxide

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F04%3A00012335" target="_blank" >RIV/60461373:22310/04:00012335 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Syntheses of 7-(2-hydroxy-1-phenylethyl)- and 7-(2-hydroxy-2-phenylethyl)guanine, DNA adducts derived from styrene 7,8-oxide
Original language description
7-Hydroxy(phenyl)ethylguanines are important DNA adducts which can be used as markers of exposure to styrene. Two synthetic routes leading to these compounds are presented using allyl protected bromohydrins as synthetic equivalents of styrene 7,8-oxide to alkylate 2-amino-6-chloropurine or 7-methyl-10-oxo-9,10-dihydropyrimido[1,2-a]purine as precursors to guanine
Czech name
Syntheses of 7-(2-hydroxy-1-phenylethyl)- and 7-(2-hydroxy-2-phenylethyl)guanine, DNA adducts derived from styrene 7,8-oxide
Czech description
Syntheses of 7-(2-hydroxy-1-phenylethyl)- and 7-(2-hydroxy-2-phenylethyl)guanine, DNA adducts derived from styrene 7,8-oxide

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
<a href="/en/project/GA310%2F03%2F0437" target="_blank" >GA310/03/0437: New aspects in understanding styrene genotoxicity: the role of DNA repair,new reactive metabolites and secondary oxidative stress</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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