Urinary N3 adenine DNA adducts in humans occupationally exposed to styrene

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F10%3A00022958" target="_blank" >RIV/60461373:22310/10:00022958 - isvavai.cz</a>

Alternative codes found

RIV/75010330:_____/10:00009029

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Urinary N3 adenine DNA adducts in humans occupationally exposed to styrene

Original language description

Urine samples from humans occupationally exposed to styrene, with mandelic acid levels ranging from 400 to 1145 mg/g creatinine and from 68 to 400 mg/g creatinine for high and low exposure group, respectively, were analysed for N3 adenine DNA adducts, namely, 3-(2-hydroxy-1-phenylethyl)adenine (N3alphaA) and 3-(2-hydroxy-2-phenylethyl)adenine (N3betaA). A sensitive LC-ESI-MSMS method was developed with the limit of quantification of 1 pg/mL for both analytes. Peaks corresponding to N3alphaA and/or N3betaA were found in 7 of 9 end-of-shift samples of the high exposure group and in 6 of 19 end-of-shift samples of the low exposure group. Concentration of N3alphaA + N3betaA amounted to 2.8 +/- 1.6 pg/mL (mean +/- S.D.; n = 9) and 1.8 +/- 1.3 pg/mL (mean +/- S.D.; n = 19) in the high and low exposure group, respectively. Of other 10 samples taken the next morning after exposure, 2 contained low but quantifiable concentrations of N3alphaA and none contained N3betaA. However, interfering peak

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

—

Project

<a href="/en/project/2B08051" target="_blank" >2B08051: New Strategy for Biological Monitoring of Exposure to Mutagens and Carcinogens</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology Letters

ISSN

0378-4274

e-ISSN

—

Volume of the periodical

197

Issue of the periodical within the volume

3

Country of publishing house

IE - IRELAND

Number of pages

5

Pages from-to

—

UT code for WoS article

000281002700005

EID of the result in the Scopus database

—