HPLC Method for Monitoring of Degradation Products in Picoplatin Stability Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F11%3A43892007" target="_blank" >RIV/60461373:22310/11:43892007 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s10337-011-1938-1" target="_blank" >http://dx.doi.org/10.1007/s10337-011-1938-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10337-011-1938-1" target="_blank" >10.1007/s10337-011-1938-1</a>
Alternative languages
Result language
angličtina
Original language name
HPLC Method for Monitoring of Degradation Products in Picoplatin Stability Study
Original language description
An analytical method combining high-performance liquid chromatography (HPLC) with UV detection was developed for an easy and rapid assay determination of the anticancer drug picoplatin (=cis-[Pt(NH3)(2-methylpyridine)Cl2]) and its degradation products. An ion exchanger was used as the stationary phase with an aqueous solution of NaH2PO4 with pH adjusted to 3.0 with H3PO4 as the mobile phase. The calibration curve was linear within the concentration range of 0.10-0.50 g L?1 (R 2 ? 0.998). The limit of detection was 0.05 g L?1 and limit of quantification was 0.09 g L?1. The developed method was characterized with a high precision (?6.0%, determined as RSD), an acceptable accuracy (the values of recovery were from intervals 98-103%). The developed methodwas used for assessing the stability of picoplatin during a stability study.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chromatographia
ISSN
0009-5893
e-ISSN
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Volume of the periodical
73
Issue of the periodical within the volume
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Country of publishing house
DE - GERMANY
Number of pages
5
Pages from-to
131-135
UT code for WoS article
000290804900015
EID of the result in the Scopus database
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