Pd-Catalyzed Allylic Substitution of Purin-8-yl(allyl) Acetate: Route to (E)-Alkenylpurines

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F11%3A43892715" target="_blank" >RIV/60461373:22310/11:43892715 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1135/cccc2011030" target="_blank" >http://dx.doi.org/10.1135/cccc2011030</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1135/cccc2011030" target="_blank" >10.1135/cccc2011030</a>

Result language
angličtina
Original language name
Pd-Catalyzed Allylic Substitution of Purin-8-yl(allyl) Acetate: Route to (E)-Alkenylpurines
Original language description
C8-Alkenylpurines were synthesized starting from purin-8-yl(allyl) acetates using Pdcatalyzed allylic substitution. The described protocol allows, by reaction of purin-8-yl(allyl) acetates with stabilized nucleophiles, an access to novel (E)-8-alkenylpurine derivatives under Pd2dba3?CHCl3 catalysis in dry THF in yields ranging from 31 to 76%. A wide range of nucleophiles showed exclusive E-alkene formation, however, ethyl nitroacetate gave mixture of E/Z-alkenes. On contrary, purin-2-yl(allyl) acetatesreacted smoothly only with dimethyl malonate.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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