Prediction of Dissolution Behavior of Final Dosage forms Prepared by Different Granulation Methods

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F12%3A43894825" target="_blank" >RIV/60461373:22310/12:43894825 - isvavai.cz</a>
Alternative codes found
RIV/62243136:_____/12:#0000285
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1877705812029463" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1877705812029463</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.proeng.2012.07.539" target="_blank" >10.1016/j.proeng.2012.07.539</a>

Result language
angličtina
Original language name
Prediction of Dissolution Behavior of Final Dosage forms Prepared by Different Granulation Methods
Original language description
The release rate of an active pharmaceutical ingredient (API) from a dosage form, measured by a dissolution test, is one of the key parameters governing the formulation viability. A number of dissolution tests have to be performed during the life cycle of a dosage form. This number can be significantly reduced by prediction of the API dissolution behavior. Thus the aim of this work was to find if, and how precisely, it is possible to predict dissolution behavior of final dosage forms by carrying out theexperiments with their precursors. In this purpose the rate of release of a model API - caffeine -from a powdered, granulated and compacted form was observed. The experiments were performed in a flow-through cell dissolution apparatus (USP 4) with agglomerates and in a paddle dissolution apparatus (USP 2) with tablets and capsules. It was found that the caffeine release from the agglomerates was retarded by the excipient matrix and that compacted caffeine dissolved faster than granulate
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
—

Project
<a href="/en/project/ED2.1.00%2F03.0071" target="_blank" >ED2.1.00/03.0071: Unipetrol Centre of Research and Education</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)