Analysis of Drug Release from Different Agglomerates Using a Mathematical Model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43898271" target="_blank" >RIV/60461373:22310/14:43898271 - isvavai.cz</a>
Result on the web
<a href="http://www.dissolutiontech.com/DTresour/201411Articles/DT201411_A04.pdf" target="_blank" >http://www.dissolutiontech.com/DTresour/201411Articles/DT201411_A04.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14227/DT210414P40" target="_blank" >10.14227/DT210414P40</a>
Alternative languages
Result language
angličtina
Original language name
Analysis of Drug Release from Different Agglomerates Using a Mathematical Model
Original language description
The release rate of an active ingredient from a dosage form may be affected by the agglomeration of an active ingredient before tablet compression. This study is aimed at establishing the effects of the agglomerates on active ingredient release profiles.A model substance, caffeine, was tested in the powdered form and in the two agglomerated forms prepared by wet granulation and compaction. The profiles of caffeine release from these forms were measured using a flow-through cell dissolution apparatus (USP 4) in an open-loop arrangement. To identify the particular processes responsible for the differences in the dissolution profiles of the model forms, we developed a mathematical description of the dissolution profiles. Using this mathematical approach,we proposed that caffeine was adsorbed to the microcrystalline cellulose present in the granulated and compacted form and that diffusion of the active ingredient was inhibited in the presence of a binder in the granulate. Both of these e
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Dissolution Technologies
ISSN
1521-298X
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
40-47
UT code for WoS article
000347437200004
EID of the result in the Scopus database
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