Effect of Maize Starch Excipient Properties on Drug Release Rate
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F12%3A43894823" target="_blank" >RIV/60461373:22310/12:43894823 - isvavai.cz</a>
Alternative codes found
RIV/62243136:_____/12:#0000288
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1877705812028391" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1877705812028391</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.proeng.2012.07.439" target="_blank" >10.1016/j.proeng.2012.07.439</a>
Alternative languages
Result language
angličtina
Original language name
Effect of Maize Starch Excipient Properties on Drug Release Rate
Original language description
The aim of the work was to determine the influence of pregelatinized maize starch properties on the dissolution rate of caffeine. The intrinsic dissolution rate apparatus was used to investigate the process of drug dissolution. Dissolution profiles of caffeine mixed with 5 different maize starch samples, using caffeine: starch ratio (4:1), were measured. The dissolution profiles of all caffeine-starch mixtures are presented, as well as the results of the mathematical model, consisting of the equations for caffeine concentration change and for the starch layer change in time. The values of 3 parameters of the dissolution model were estimated using non-linear regression analysis. Caffeine effective diffusivity in swollen starch layer was found to be strongly related to the starch swelling capacity.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED2.1.00%2F03.0071" target="_blank" >ED2.1.00/03.0071: Unipetrol Centre of Research and Education</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Procedia Engineering
ISSN
1877-7058
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
September
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
482-488
UT code for WoS article
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EID of the result in the Scopus database
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